[Angiotensin converting enzyme (ACE) in scalded rats and protective effect of chloroquine (CQ) in lung injury].
Identifieur interne : 002D11 ( Main/Exploration ); précédent : 002D10; suivant : 002D12[Angiotensin converting enzyme (ACE) in scalded rats and protective effect of chloroquine (CQ) in lung injury].
Auteurs : L B Xue [République populaire de Chine]Source :
- Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns [ 1000-7806 ] ; 1993.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Poumon.
- enzymologie : Brûlures.
- métabolisme : Peptidyl-Dipeptidase A.
- traitement médicamenteux : Brûlures.
- usage thérapeutique : Chloroquine.
- Animaux, Attribution aléatoire, Oedème pulmonaire, Rat Wistar, Rats.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Peptidyl-Dipeptidase A.
- chemical , therapeutic use : Chloroquine.
- drug therapy : Burns.
- enzymology : Burns.
- pathology : Lung.
- prevention & control : Pulmonary Edema.
- Animals, Random Allocation, Rats, Rats, Wistar.
Abstract
Wistar rats were scalded and then divided at random into control group and scalded+CQ group. They were sacrificed in lots at 6, 24 and 48 hours after the scald and blood was drawn for the determination of ACE, PLAa, Pa02. Pathological examination was also done. The results revealed that, 1. after scald, the rat's serum ACE was reduced below normal value, and it occurred before changes in blood gas, suggesting that ACE might be used as a valuable supplementary diagnostic criterion for pulmonary failure; 2. CQ provided certain amount of protection in pulmonary failure of scalded rat.
PubMed: 8221327
Affiliations:
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Le document en format XML
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Xue</name><affiliation wicri:level="3"><nlm:affiliation>Trauma Center, Postgraduate Medicai College of PLA, 304th Hospital of PLA, Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:orgArea>Trauma Center, Postgraduate Medicai College of PLA, 304th Hospital of PLA</wicri:orgArea></affiliation></author></analytic><series><title level="j">Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns</title><idno type="ISSN">1000-7806</idno><imprint><date when="1993" type="published">1993</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Burns (drug therapy)</term><term>Burns (enzymology)</term><term>Chloroquine (therapeutic use)</term><term>Lung (pathology)</term><term>Peptidyl-Dipeptidase A (metabolism)</term><term>Pulmonary Edema (prevention & control)</term><term>Random Allocation</term><term>Rats</term><term>Rats, Wistar</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Attribution aléatoire</term><term>Brûlures (enzymologie)</term><term>Brûlures (traitement médicamenteux)</term><term>Chloroquine (usage thérapeutique)</term><term>Oedème pulmonaire ()</term><term>Peptidyl-Dipeptidase A (métabolisme)</term><term>Poumon (anatomopathologie)</term><term>Rat Wistar</term><term>Rats</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Peptidyl-Dipeptidase A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Chloroquine</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Burns</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Brûlures</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Burns</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Peptidyl-Dipeptidase A</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Pulmonary Edema</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Brûlures</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Chloroquine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Random Allocation</term><term>Rats</term><term>Rats, Wistar</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Attribution aléatoire</term><term>Oedème pulmonaire</term><term>Rat Wistar</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Wistar rats were scalded and then divided at random into control group and scalded+CQ group. They were sacrificed in lots at 6, 24 and 48 hours after the scald and blood was drawn for the determination of ACE, PLAa, Pa02. Pathological examination was also done. The results revealed that, 1. after scald, the rat's serum ACE was reduced below normal value, and it occurred before changes in blood gas, suggesting that ACE might be used as a valuable supplementary diagnostic criterion for pulmonary failure; 2. CQ provided certain amount of protection in pulmonary failure of scalded rat.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Xue, L B" sort="Xue, L B" uniqKey="Xue L" first="L B" last="Xue">L B Xue</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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